Chronic Actinic Cheilitis

Ingenol Mebutate for Recalcitrant Chronic Actinic Cheilitis.

We present the case of a healthy 76-year-old man with a whitish, hyperkeratotic lesion of the lower lip diagnosed as actinic cheilitis (AC) previously treated with classic red light photodynamic therapy 5 years ago. Initial treatment with 5% imiquimod cream - also with intensified application - failed. After 2 cycles thrice daily, consecutive applications of 150 μg/g ingenol mebutate gel at 3 w...

[Photodynamic therapy for actinic cheilitis].

Actinic cheilitis is a subtype of actinic keratosis that mainly affects the lower lip and has a higher risk of malignant transformation. Its location on the labial mucosa influences the therapeutic approach. Vermilionectomy requires local or general anesthetic and is associated with a risk of an unsightly scar, and the treatment with 5-fluorouracil or imiquimod lasts for several weeks and the i...

Dermoscopic features of plasma cell cheilitis and actinic cheilitis.

Chronic Oral Breathing as a Risk Factor for the Development of Actinic Cheilitis

Chronic oral breathing is characterized by respiratory and anatomic alterations found in children who breathe through their mouth only. Through open-mouth breathing, these patients develop anatomic deformities such as a typical adenoid facies. Such anatomic alterations make the lower lip of these patients more prone to UV action and its related actinic damage. This paper discusses an 11-year-ol...

p53 AND MDM2 PROTEIN EXPRESSION IN ACTINIC CHEILITIS

Actinic cheilitis is a potentially malignant lip lesion caused by excessive and prolonged exposure to ultraviolet radiation, which can lead to histomorphological alterations indicative of abnormal cell differentiation. In this pathology, varying degrees of epithelial dysplasia may be found. There are few published studies regarding the p53 and MDM2 proteins in actinic cheilitis. Fifty-eight cas...